IMO Proposal 3: Oogway—Revolutionizing Longevity Research with AI & DeSci

1. About Oogway

Oogway is the first memecoin combining Al innovation and longevity research funding. Powered by memes and decentralized community governance, Oogway empowers individuals to participate in shaping the future of life extension science.
Oogway is a pioneering project that leverages AI and decentralized science (DeSci) to revolutionize longevity research. By combining cutting-edge AI insights with community-driven governance, Oogway aims to address humanity’s greatest challenge: aging. The project focuses on democratizing access to health advancements, empowering individuals and communities to shape the future of longevity research and extending the human lifespan.
Website: https://oogwaylongevity.com/

2. Motivation

Aging remains one of humanity’s most significant challenges, and artificial intelligence (AI) has the potential to redefine how we approach this timeless issue. Traditional longevity research is often constrained by resource limitations, centralized control, and slow progress. Oogway seeks to overcome these barriers by developing open-source AI models dedicated to advancing longevity science.

Our approach focuses on creating models that are accessible, transparent, and impactful. By democratizing AI tools, Oogway empowers researchers, developers, and communities worldwide to contribute to breakthroughs in understanding aging and developing actionable interventions. Key motivations include:

  1. AI for Aging Mechanism Analysis: Open-source AI models can simulate biological networks to uncover key genes, proteins, and molecular pathways related to aging, enabling researchers to focus on high-impact areas.
  2. Personalized Health Optimization: AI-driven models can analyze genetic, metabolic, and lifestyle data, providing tailored health and longevity recommendations, making cutting-edge solutions accessible to everyone.
  3. Collaboration and Transparency: By maintaining open-source frameworks, Oogway ensures that advancements in longevity research are shared across the global scientific community, fostering faster innovation and collaboration.
  4. Scalable Solutions for Global Impact: Open-source AI models allow for widespread adoption, ensuring that even under-resourced regions can access transformative tools for health and aging.

Oogway’s open-source commitment aligns with the principles of transparency and inclusivity, ensuring that AI-driven longevity advancements benefit all of humanity. By contributing to the IMO, Oogway aims to accelerate the development of these critical AI models, supported by GPU resources and a collaborative ecosystem.

3. Methodology

3.1 Dataset Collection and Preparation

3.1.1 Data Sources
  • Academic Research Papers: Collect open-access papers and preprints from PubMed, NIH databases, ArXiv, and BioRxiv related to longevity, anti-aging, and wellness science.
  • Clinical Studies: Extract relevant data from publicly available clinical trials (e.g., ClinicalTrials.gov) focusing on dietary interventions, exercise regimens, and aging biomarkers.
  • Authoritative Blogs and Tweets: Include longevity-focused expert blogs (e.g., by scientists or physicians) and tweets for actionable tips and layman-friendly insights.
  • Public Forums and Q&A: Scrape anonymized data from platforms like Reddit (longevity forums) and Quora to capture common user concerns and informal language patterns.
  • Ontology Development: Create a longevity ontology with structured metadata for topics such as:
    • Dietary strategies (e.g., calorie restriction, fasting).
    • Exercise types (e.g., resistance training, yoga).
    • Supplements (e.g., NAD+, resveratrol).
    • Sleep science and circadian rhythms.
3.1.2 Data Cleaning and Preprocessing
  • Deduplication: Remove duplicate or redundant entries to optimize the training process.
  • Normalization: Convert data into consistent formats (e.g., removing LaTeX artifacts from papers).
  • Annotation: Use semi-automated tools (like Prodigy or Label Studio) to annotate key concepts, sentiment, and relevancy.
  • Language Simplification: Translate complex technical terms into accessible language using automated summarization techniques.
3.1.3 Validation
  • Validate datasets through cross-referencing with domain experts to ensure data accuracy and reliability.

3.2 Fine-Tuning with RAG (Retrieval-Augmented Generation)

3.2.1 Model Selection
  • Utilize LLaMA 3 8B, a state-of-the-art open-source LLM known for its efficiency and scalability.
3.2.2 RAG Workflow
  • Knowledge Base Construction:
    • Use vector databases like Pinecone, Weaviate, or FAISS to store preprocessed datasets as embeddings.
    • Implement document chunking (e.g., 512-1024 token length) for efficient retrieval during inference.
  • Query Retrieval:
    • When the chatbot receives a query, retrieve the most relevant chunks from the knowledge base using similarity search (e.g., cosine similarity with BERT embeddings).
  • Model Integration:
    • Combine retrieved-context with the original user query as input to the LLaMA 3 8B model.
    • Fine-tune the model to effectively utilize retrieved data for coherent and accurate responses.

3.2.3 Knowledge Graph Integration

The Knowledge Graph serves as the backbone for storing and querying structured and unstructured data related to longevity research. It is built from various data sources and helps provide rich, context-aware insights for fine-tuning models in the Retrieval-Augmented Generation (RAG) pipeline.

Key Components:

  • Nodes (Entities): Represent important concepts in longevity research such as dietary strategies, biomarkers, supplements, and exercise types. For example, “Calorie Restriction,” “NAD+,” and “Telomeres.”
  • Edges (Relationships): Capture the connections between entities based on research findings. For example, “Calorie Restriction” → “Increased Lifespan,” or “NAD+” → “Cellular Repair.”
  • Metadata: Includes additional information about each relationship such as study outcomes, citations, and confidence levels to validate data relevance and accuracy.
3.2.4 Reinforcement Learning from Human Feedback (RLHF)
  • Use RLHF to enhance the model’s ability to provide accurate, conversational, and user-specific responses.

3.3 Prompt Engineering for Enhanced Responses

3.3.1 Design Principles
  • Structured Outputs: Ensure responses follow specific formats, e.g.:
    • Q&A: “The main benefits of fasting include…”
    • Lists: “Here are three tips to improve your longevity: 1. Regular exercise; 2. Quality sleep; 3. Healthy diet.”
  • Context Sensitivity: Enable adaptive prompts for a nuanced understanding of user queries, e.g.:
    • Initial Query: “What supplements help with aging?”
    • Follow-up Query: “How does that compare with resveratrol?”
  • Multilingual Support: Add support for basic localization to engage broader audiences.
3.3.2 Prompt Templates
  • Fact Retrieval:
    • Template: “Based on research from [source], the recommended practice for [topic] is [key insight].”
  • Recommendation:
    • Template: “For [user’s condition or preference], [actionable advice] is effective according to studies.”
  • Dynamic Reframing:
    • Template: “Here’s an overview of [topic]: [summary]. For more, you can explore these options: [list].”

3.4 Deployment Architecture

3.4.1 Centralized Infrastructure
  • Cloud Hosting:
    • Use AWS (SageMaker), Google Cloud (Vertex AI), or Azure ML for hosting the fine-tuned LLaMA model and RAG components.
  • Deployment Steps:
    • Containerize the application using Docker.
    • Use Kubernetes for orchestration, ensuring horizontal scaling during peak usage.
  • API Gateway:
    • Integrate with RESTful APIs to enable seamless communication between the chatbot frontend and backend.
    • Monitor traffic using tools like Prometheus and Grafana.
3.4.2 Decentralized Infrastructure
  • Edge Deployment:
    • Use edge platforms (e.g., Cloudflare Workers, Hugging Face Spaces) to host lightweight RAG components, minimizing latency.
  • On-Device Inference:
    • Optimize a smaller distilled version of the LLaMA model for on-device inference (e.g., Android/iOS).
    • Use frameworks like TensorFlow Lite or ONNX Runtime for edge compatibility.
  • Distributed Storage:
    • Leverage IPFS or Filecoin to store academic datasets securely in a decentralized manner.

3.5 Testing and Monitoring

3.5.1 Testing Framework
  • Use Pytest and Locust to simulate user queries and evaluate response times, accuracy, and contextual relevance.
3.5.2 Metrics and Monitoring
  • Track key metrics like:
    • Response accuracy (benchmarked against domain expert evaluations).
    • Latency (end-to-end response time <1 second).
    • User satisfaction (collected via feedback prompts).
  • Integrate monitoring tools such as Sentry (error tracking) and Datadog (performance analysis).

4. Expected Outcomes:

4.1 Enhanced User Engagement and Accessibility

  • Provide personalized advice based on user preferences, health goals, or lifestyle inputs, fostering deeper trust and long-term interaction with the system.
  • Make high-quality, research-backed knowledge accessible to a global audience, breaking barriers posed by technical language and paywalls.

4.2 Scalable and Reliable Architecture

  • Deploy a robust architecture that supports both centralized cloud hosting for global scalability and decentralized infrastructure for localized, low-latency operations.
  • Enable seamless integration with future AI modules, expanding the chatbot’s scope beyond longevity to other wellness topics.

4.3 Broader Ecosystem Integration Potential

  • Offer an adaptable framework for integrating with ORA’s existing ecosystem, such as customer engagement platforms, data dashboards, or personalized wellness recommendations.
  • Enable API access for third-party developers to build complementary tools, encouraging broader adoption of the chatbot.

4.4 Community Building and Social Media Presence

  • Leverage AI to actively engage with the longevity community through insightful, research-driven Twitter posts.
  • Strengthen the brand’s position as a thought leader in longevity and wellness by fostering an informed and interactive community.

4.5 Foundational Framework for Future Innovations

  • Establish a scalable and efficient infrastructure capable of supporting future features like multimedia content delivery, multi-language support, and integration with wearables or health-tracking devices.
  • Enable continuous improvement through feedback loops and model fine-tuning, ensuring the chatbot remains relevant in the rapidly evolving field of longevity.

5. Resource Requirements

5.1 Hardware and Compute Resources

  • Training Phase:
    • Computing: 4 NVIDIA A100 GPUs (80GB) or equivalent high-performance GPUs to handle distributed training efficiently.
    • Memory and Storage:
      • 1TB of storage for training datasets, embeddings, and model checkpoints.
      • High-speed NVMe storage for intermediate data processing.
  • Inference Phase:
    • Computing: 2 NVIDIA A100 GPUs (80GB) for low-latency real-time inference during chatbot interactions.
    • Memory and Storage: 500GB of storage for the production model, embeddings, and API deployment infrastructure.

5.2 Infrastructure

  • Centralized Deployment:
    • Cloud hosting on AWS (SageMaker), Google Cloud (Vertex AI), or Azure ML to scale model training and deployment.
    • Utilize Kubernetes or AWS ECS for container orchestration to ensure reliability and scalability.
    • Leverage high-bandwidth cloud networking to support rapid model queries and API calls.
  • Decentralized Deployment:
    • Edge infrastructure for local deployment using Cloudflare Workers or Hugging Face Spaces to minimize latency for global users.
    • Distributed storage using IPFS or Filecoin for secure and decentralized management of academic datasets.

5.3 Software Tools and Libraries

  • Model Fine-Tuning:
    • Frameworks: PyTorch, Hugging Face Transformers, and DeepSpeed for efficient training and inference.
    • RAG Components: Use libraries like Haystack or LangChain for building the retrieval pipeline.
  • Data Management:
    • Preprocessing: Pandas, spaCy, and NLTK for data cleaning and preparation.
    • Embedding Storage: Pinecone, FAISS, or Weaviate for vector database management.
  • Frontend and API Development:
    • Frontend: React.js or Vue.js for chatbot UI development.
    • Backend: FastAPI or Flask for API integration with the chatbot and RAG pipeline.

6. Contact Information: TG Contact: @clairechan3

2 Likes

Love this proposal! I’m curious, how would you ensure the AI model can provide recommendations with confidence to users? For example, some research becomes outdated over time, or some suggestions by ‘longevity experts’ may not have the appropriate weight of research backing. How will you ensure that the AI can provide a comprehensive response that takes all of this into account in a way that is ethical? The RAG capability will help, but I wonder if there’s some system prompt to supplement this…

I mention this because I am excited at the prospect of an AI Longevity model that can provide its own insight (like a meta-analysis study) into what longevity recommendations hold more weight than others, perhaps even going as far as to suggest what therapies warrant deeper study. In particular, with regard to the individual.

TLDR: i’m curious how you could engineer this model to provide new insights from its wealth of training data, rather than just acting as a research assistant for longevity.